Aldosterone and the Metabolic Syndrome

Women left out

• No pregnant women

  Women who were pregnant could not join.

  “Pregnancy”

• No breastfeeding moms

  Women who were breastfeeding could not join.

  “Breast-feeding”

• Had to use birth control

  Women who couldn't or didn't want to use birth control were turned away.

  “if of childbearing potential, utilization of adequate birth control and willingness to undergo urine beta-hcg testing prior to drug treatment and on every study day.”

• No hormone therapy

  Women taking menopause hormones or gender-affirming hormones could not join.

  “Use of hormone replacement therapy”

• Only women past menopause

  Women who could still get pregnant were turned away.

  “postmenopausal status for at least 1 year, or”

• No kidney or liver problems

  Women with kidney or liver problems were turned away.

  “…ired renal function \[estimated glomerular filtration rate (eGFR) of \<60ml/min\] as determined by the four-variable Modification of Diet in Renal Disease (MDRD) equation, where serum creatinine (Scr) is expressed in mg/dl and age in years:”

• No heart disease

  Women with heart disease, heart rhythm problems or a past heart attack were turned away.

  “Cardiovascular disease such as prior myocardial infarction, presence of angina pectoris, significant arrhythmia, congestive heart failure \[Left Ventricular (LV) hypertrophy acceptable\], deep vein thrombosis, pulmonary embolism, second or…”

• No diabetes

  Women with diabetes were turned away.

  “Diabetes type 1 or type 2, a fasting glucose of greater than 110 mg/dL or the use of anti-diabetic medication”

• No seizures

  Women with epilepsy or past seizures were turned away.

  “History of serious neurologic disease such as cerebral hemorrhage, stroke, seizure, or transient ischemic attack”

Study titles and rules are shown in their original English.