Women were less than half of the people tested for almost all of these common medicines.
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NCT00347360

The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial

See it on ClinicalTrials.gov ↗

654 people

232 womenmiddle line = equal numbers422 men
Phase
PHASE3
Paid for by
GlaxoSmithKline
Finished
2008-04
Health conditions
Hypertension
Who could join
Anyone
Ages
18 Years – no maximum
Average age
mean 53.1 years
Age 65+
Not reported
Weight (BMI)
Not reported
Pregnancy recorded
Not reported
Menopause recorded
Not reported
Results shown by sex
Not split by sex
Race
White 63.8% · Black / African American 29.7% · Asian 5% · Other 1.1% · American Indian / Alaska Native 0.3% · Native Hawaiian / Pacific Islander 0.2%

Women left out

  • No pregnant women

    Women who were pregnant could not join.

    “…(i.e., no menstrual period for a minimum of 12 months prior to Screening) or surgically sterilized are eligible for the study. If judged appropriate, a postmenopausal woman may be required to have a documented negative urine pregnancy test.”
  • No women who could get pregnant

    Most women roughly 15–50 years old were turned away.

    “Is female of childbearing potential. NOTE: Female subjects who are postmenopausal (i.e., no menstrual period for a minimum of 12 months prior to Screening) or surgically sterilized are eligible for the study. If judged appropriate, a postme…”
  • No kidney or liver problems

    Women with kidney or liver problems were turned away.

    “renal disease defined as estimated Glomerular Filtration Rate (eGFR) \<30mL/min per 1.73 m2 hepatic disease (i.e., ALT or AST levels greater than three times the upper limit of normal range, history of hepatic impairment, or by clinical ass…”
  • No heart disease

    Women with heart disease, heart rhythm problems or a past heart attack were turned away.

    “uncontrollable or symptomatic arrhythmias unstable angina or angina treated with a beta-blocker sick sinus syndrome or second or third degree heart block (unless treated with a permanent, functioning pacemaker) bradycardia (sitting heart ra…”
  • No diabetes

    Women with diabetes were turned away.

    “Subject has DBP =90 mmHg (or for diabetic subjects, DBP =80 mmHg) on two antihypertensive medications.”
  • No cancer

    Women with current or past cancer were turned away.

    “Subject has malignant (accelerated) hypertension, history of malignant hypertension, or secondary forms of hypertension.”

Study titles and rules are shown in their original English.