NCT02696564
Losartan Effects on Emphysema Progression
See it on ClinicalTrials.gov ↗220 people
42.3%
57.7%
93 womenmiddle line = equal numbers127 men
- Phase
- PHASE4
- Paid for by
- JHSPH Center for Clinical Trials
- Finished
- 2021-06-30
- Health conditions
- Emphysema
- Who could join
- Anyone
- Ages
- 40 Years – no maximum
- Average age
- median 65 years
- Age 65+
- Not reported
- Weight (BMI)
- median 26 kg/m^2
- Pregnancy recorded
- Not reported
- Menopause recorded
- Not reported
- Results shown by sex
- Not split by sex
- Race
- White 80% · Black / African American 19.1% · Other 0.9%
Women left out
- No pregnant women
Women who were pregnant could not join.
“For women of child bearing potential, positive pregnancy test or unwillingness to use two methods of birth control or abstinence for the duration of the study”
- Had to use birth control
Women who couldn't or didn't want to use birth control were turned away.
“For women of child bearing potential, positive pregnancy test or unwillingness to use two methods of birth control or abstinence for the duration of the study”
- No kidney or liver problems
Women with kidney or liver problems were turned away.
“Renal insufficiency (GFR \<30 mL/min by Cockcroft-Gault calculation)”
- No heart disease
Women with heart disease, heart rhythm problems or a past heart attack were turned away.
“Conventional indication for ACE inhibitor or ARB (e.g., history of myocardial infarction, known cardiomyopathy)”
- No diabetes
Women with diabetes were turned away.
“….5x normal upper limit), neurological, psychiatric, endocrine or neoplastic diseases, uncontrolled diabetes, uncontrolled HIV infection or other immune system disorder, hyperthyroidism, seizure disorders, non-skin cancer, rheumatic diseases”
- No seizures
Women with epilepsy or past seizures were turned away.
“….5x normal upper limit), neurological, psychiatric, endocrine or neoplastic diseases, uncontrolled diabetes, uncontrolled HIV infection or other immune system disorder, hyperthyroidism, seizure disorders, non-skin cancer, rheumatic diseases”
- No mental health conditions
Women with depression, bipolar disorder or other mental health conditions were turned away.
“…cardiac, renal, hepatic (LFTs more than 2.5x normal upper limit), neurological, psychiatric, endocrine or neoplastic diseases, uncontrolled diabetes, uncontrolled HIV infection or other immune system disorder, hyperthyroidism, seizure disor…”
- No cancer
Women with current or past cancer were turned away.
“….5x normal upper limit), neurological, psychiatric, endocrine or neoplastic diseases, uncontrolled diabetes, uncontrolled HIV infection or other immune system disorder, hyperthyroidism, seizure disorders, non-skin cancer, rheumatic diseases”
Study titles and rules are shown in their original English.