High blood pressure
amlodipine
Dozens of side effects are reported more often by women, but women were under 45% of the people in its studies.
- 44.3%
of the people in the studies were women
- 55%
of studies did not allow pregnant women
- 3%
looked at results for women separately
Was someone like me tested?
Choose the group that fits you.
Not one of these studies reported results separately for any of the groups below.
Pregnant women
55% of studies would not let pregnant women join. Only 2 small studies (191 women in all) looked at pregnancy or just after birth.
What do we know?
What the FDA drug label says
There is too little information to know if it causes birth defects or miscarriage.
Studies focused on this group (2)
- Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension · 175 people · results posted
- Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation · 16 people · results posted
Good to know
Ankle and leg swelling is a common side effect and happens more often in women.
What women report more
Compared with men taking the same medicine.
- 2.1×Changes to the front of the eye
- 2.0×Nerve-coating damage (like MS-type symptoms)
- 1.9×Broken bones
- 1.8×Ear problems
How many times more often women reported each problem than men taking the same medicine, based on reports to the FDA. This is a warning sign, not proof the medicine caused it.
Make it about you
Check it against your medicines
Check amlodipine against the medicines, pregnancy and birth control in your profile.
Join to checkAll the details
Every number behind this page.
Who was in the studies
85,533 people in 133 studies
Race
- White72.9%
- Black / African American17.8%
- Asian4.3%
- More than one race0.3%
- Other0.2%
Studies didn't say how many of the women were Black, Asian or another race — only totals for everyone.
- Hispanic or Latina
- 10.7%
- Age 65 or older
- 43%
- Studies with men only
- 5
- Studies with women only
- 4
Rules that kept women out
Share of studies with each rule.
- 59%
No heart disease
Women with heart disease, heart rhythm problems or a past heart attack were turned away.
See the exact rule
“Subjects having a history of the following within the last six months: myocardial infarction (MI), unstable angina pectoris, percutaneous coronary intervention, heart failure, hypertensive encephalopathy, cerebrovascular accident (stroke),…” NCT00923091
- 55%
No pregnant women
Women who were pregnant could not join.
See the exact rule
“Women who are pregnant or of child-bearing potential” NCT02068495
- 35%
No breastfeeding moms
Women who were breastfeeding could not join.
See the exact rule
“Female subjects of childbearing potential who are pregnant or lactating.” NCT00923091
- 34%
No diabetes
Women with diabetes were turned away.
See the exact rule
“Subjects with uncontrolled Type 1 or Type 2 diabetes defined as HbA1c \> 9.0%. Diabetics must have documentation of HbA1c within 6 months of the Screening Visit, or must have their HbA1c assessed prior to randomisation. Note: subjects with…” NCT00923091
- 28%
No cancer
Women with current or past cancer were turned away.
See the exact rule
“Subjects with a history of a wasting disease (e.g. cancer), autoimmune diseases, connective tissue diseases, major allergies or angioneurotic oedema.” NCT00923091
- 26%
Had to use birth control
Women who couldn't or didn't want to use birth control were turned away.
See the exact rule
“Will practice birth control throughout the study by the following: oral or patch contraceptive, injectable or implantable contraceptive medication, intrauterine device, diaphragm or female condom plus spermicide” NCT00649389
What nobody checked
Share of studies that recorded each thing.
- 3%Results shown separately for women
- 0%Whether anyone was pregnant
- 0%Whether women were past menopause
- 13%Body weight (BMI)
- 12%Hispanic / Latina or not
- 28%Race
All 136 studies
Study titles and rules are shown in their original English.